Recurrent episodes of C. difficile continue to pose a significant burden on patients, clinicians, and the healthcare system. The management of recurrent and refractory C. difficile is complex and challenging. Participate in one or all three of these activities and earn CME/CPE credits. Join our faculty as they review the role of the gut microbiome in C. difficile infection, discuss evidence-based guidelines for treatment and prevention of recurrent infection, and describe emerging restoration approaches that reduce complications and improve clinical outcomes.

Three activities:

• Sparing and Restoring the Gut Microbiota: A Faculty Review of Recent Abstracts and Literature in C. difficile (0.5 CME)
• Non-Antimicrobial Approaches for Recurrent C. difficile: What’s New on the Horizon? (0.75 CME)
• Clinical Case Challenges: Treatment of C. difficile Infection (0.5 CME)

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Learning objectives

• Upon completion of this activity, participants will be able to:
• Explain the role of the gut microbiome in relationship to C. difficile infection and approaches to restoration for prevention of recurrent infection
• Discuss the changing epidemiology of community and healthcare-associated C. difficile infection
• Describe available and emerging approaches for patients with recurrent C. difficile who have failed appropriate antibiotic therapy
• Discuss the selection of antimicrobials considerate of their impact on gut microbiota and the of antitoxins in the treatment and prevention of recurrent CDI
• Assess available and updated clinical guidelines to ensure evidence-based therapeutic selection for treatment and prevention of recurrent CDI
• Describe clinical risk factors that increase a patient’s risk for recurrent and multiply recurrent C. difficile infection
• Discuss the role of antitoxins in the treatment and prevention of recurrent CDI

Faculty

Paul Feuerstadt, MD, FACG, AGAF
Gastroenterology Center of Connecticut
Assistant Clinical Professor of Medicine
Yale University School of Medicine
Hamden, CT

Kevin W. Garey, PharmD, MS
Professor and Chair
University of Houston College of Pharmacy
Houston, TX

Sahil Khanna, MBBS, MS
Associate Professor of Medicine
Gastroenterology and Hepatology
Mayo Clinic
Rochester, MN

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